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谷歌Gemma下载量破10亿次 AI深度探索癌症治疗新机制_我的网站

一 |     The 2025 MAMA Awards is taking place in Hong Kong in a subdued manner. This is because Hong Kong is facing the worst fire in more than 100 years. It tore through several high-rise buildings and has claimed many lives. Despite so, the MAMA Awards have announced some of its winners on its first day. The winners for the categories announced include Best New Artist, Song Of The Year, Fans' Choice Awards, Favourite Global Performer, Favourite Male and Female groups and more.While HYBE's new group CORTIS has won the Best New Artist category, ROSÉ and Bruno Mars' APT has swept off the Song Of The Year category. Amongst the other categories, IVE has emerged victorious as the Favourite Global Performer and Favourite Female group. BOYNEXTDOOR has won the Favourite Male group category.Take a look at the winners announced on Day 1:BEST NEW ARTIST          WINNER: CORTIS     WINNER: Hearts2Hearts     AHOF     ALLDAY PROJECT     Baby DONT Cry     CLOSE YOUR EYES     IDID     izna     KickFlip     KiiiKiii2025 MAMA AWARDS SONG OF THE YEAR          WINNER: ROSÉ and Bruno Mars – APT     aespa – Dirty Work     aespa – Whiplash     ALLDAY PROJECT – FAMOUS     ALLDAY PROJECT – WICKED     BABYMONSTER – DRIP     BIG Naughty – MUSIC (feat. Lee Chanhyuk)     BLACKPINK – JUMP     BOYNEXTDOOR – IF I SAY, I LOVE YOU     BOYNEXTDOOR – Never Loved This Way Before     CNBLUE – A Sleepless Night     CORTIS – GO!     Davichi – Stitching     DAY6 – Maybe Tomorrow     Dayoung – body     Doyoung – Memory     Dynamic Duo and Gummy – Take Care     G-Dragon – TOO BAD (feat. Anderson .Paak)     HAON – Skrr (feat. Giselle)     HIGHLIGHT – Endless Ending     HUNTR/X – GOLDEN     ILLIT – Cherish (My Love)     IVE – REBEL HEART     j-hope – MONA LISA     Jennie – like JENNIE     Jennie – ZEN     Jennie and Doechii – ExtraL     Jisoo – earthquake     Kai – Wait On Me     Karina – UP     Key – HUNTER     LE SSERAFIM – HOT     Lee Chanhyuk – Vivid LaLa Love     Lee Mu Jin – Coming of Age Story     Mark – 1999     Mark – Fraktsiya (feat. Lee Young Ji)     MEOVV – DROP TOP     Minnie – HER     N.Flying – Everlasting     NCT DREAM – WHEN I’M WITH YOU     NCT WISH – poppop     Park Hyo Shin – HERO     pH-1 – Life Is A Movie (feat. Jung Zi So)     PLAVE – Dash     QWER – Dear     RIIZE – Fly Up     ROSÉ – toxic till the end     Roy Kim – If You Ask Me What Love Is     Saja Boys – Soda Pop     SEVENTEEN – THUNDER     Tablo and RM – Stop The Rain     Taeyeon – Letter To Myself     TREASURE – YELLOW     TWS – Countdown     TXT – When the Day Comes     V – Winter Ahead (with Park Hyo Shin)     Xdinary Heroes – Beautiful Life     ZEROBASEONE – Doctor! Doctor!Fans’ Choice Male (Top 10)          WINNERS: Baekhyun, SEVENTEEN, Jin, ENHYPEN, G-DRAGON, j-hope, NCT DREAM, RIIZE, Stray Kids, ZEROBASEONEOther nominees from this category:          10CM     82MAJOR     8TURN     AB6IX     AHOF     AMPERS&ONE     ARrC     ASTRO     ATEEZ     BOYNEXTDOOR     BTOB     CLOSE YOUR EYES     CNBLUE     CORTIS     CRAVITY     D.O. (Doh Kyung Soo)     Daesung     DAY6     Doyoung     Epik High     EVNNE     GOT7     IDID     Jay Park     Kai     KickFlip     Lee Mu Jin     N.Flying     NCT WISH     NEXZ     P1Harmony     PLAVE     SHINee     Super Junior     TIOT     TREASURE     TWS     TOMORROW X TOGETHER     WayV     Xdinary HeroesFans’ Choice Female (Top 10)     WINNERS: IRENE, IU, ILLIT, aespa, BABYMONSTER, Hearts2Hearts, i-dle, ITZY, LE SSERAFIM, TWICEOther nominees from this category:          ALLDAY PROJECT     Apink     ARTMS     AtHeart     Baby DONT Cry     BIBI     Billlie     BLACKPINK     BoA     BOL4     Chungha     Chuu     Davichi     FIFTY FIFTY     fromis_9     H1-KEY     Hwasa     Hyolyn     IVE     izna     Jeon Somi     Joy     KARD     Kep1er     KiiiKiii     KISS OF LIFE     MEOVV     NiziU     NMIXX     OH MY GIRL     QWER     SAY MY NAME     Seulgi     STAYC     Taeyeon     tripleS     UNIS     VIVIZ     Wendy     YenaAdditional WinnersFavourite Global Performer     IVETELASA Favourite Global Artist          ENHYPENFavourite Female Group          IVEFavourite Male Group          BOYNEXTDOORGlobal Trend Song          IVE - REBEL HEARTInspiring Achievement          SUPER JUNIORVISA Fans' Choice Of The Year          ENHYPENALSO READ: Full list of winners of the 2024 MAMA Awards。    　　当地时间8月20日，谷歌宣布，其开源端侧模型家族Gemma的总下载量已突破10亿次。这款由谷歌DeepMind推出的开源大模型，自发布以来，全球开发者基于它衍生出超10万个定制变体，形成名为“Gemmaverse”的开源生态。
　　谷歌列举了多个Gemma家族应用场景：从太空本地图像分析、医疗报告标准数字化、癌症创新治疗方案再到动物语言识别，Gemma家族模型正实实在在地应用到各个垂直行业。　　其中，以Gemma为基座的模型在生物医药科研领域产出了多项标志性成果。谷歌一方面推出面向医疗场景的垂直模型MedGemma，支撑医疗报告结构化、医学影像辅助分析等应用；另一方面联合科研机构，依托Gemma底座攻坚癌症机制研究。　　其中最受行业关注的是谷歌DeepMind、谷歌研究院与耶鲁大学合作开发的Cell2Sentence-Scale 27B（C2S-Scale）模型。　　传统的癌症疫苗治疗思路，是让免疫系统通过识别身份标签来识别敌人。

二 | 但这面临一个“瞄准困境”：一般来说，肿瘤的“身份标签”取自肿瘤本身,但很多肿瘤细胞表面缺少能被免疫T细胞识别的、独特的“身份标签”（即肿瘤特异性抗原），同时，它们还主动穿上“防护服”（如高表达PD-L1蛋白），成为所谓的“冷肿瘤”。

三 | 结果就是，对于“冷肿瘤”，免疫系统即使大军压境，也像得了“脸盲症”，看不见敌人，或者看见了也被强行抑制，导致治疗无效。　　针对免疫治疗难以起效的“冷肿瘤”难题，C2S-Scale按活跃程度排序，将单细胞基因表达数据转化为类文本的“基因句子”，让大语言模型能直接“读”懂细胞。随后，该模型完成4000余种药物的虚拟筛选，预测出silmitasertib联合低剂量干扰素的用药组合。

四 | 　　C2S-Scale锁定的候选药物中，仅10%-30%在过往文献中被提及，其余与筛选目标无已知关联。

五 | 最终被选中的是silmitasertib（CX-4945），一种CK2激酶抑制剂。　　这一AI提出的全新治疗假说，后续在人源活细胞实验中得到验证，研究团队用模型训练时从未见过的人类神经内分泌细胞进行实验，结果是单独用药无效果，单用低剂量干扰素只有轻微提升，两者联用后抗原呈递提升约50%，证实联用方案可显著提升抗原呈递水平，属于少数AI产出全新癌症治疗机制并获得实验室验证的案例，有望提升肿瘤细胞抗原呈递能力，把冷肿瘤转化为对免疫治疗敏感的热肿瘤。　　该模型相关成果已对外开源，可供全球科研团队继续拓展研究。需要注意的是，该发现目前仅停留在体外细胞实验阶段，尚未进入临床。　　随着下载量冲高，Gemma证明开源大模型不再局限对话生成，能够直接介入原始生物数据挖掘，深度探索癌症治疗新机制，为AI医药科研提供低成本的技术底座。（文章来源：科创板日报）。

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